If you’re searching for the best weight loss treatments in the UK, two popular names stand out: Orlistat and Wegovy. But how do they compare?
In this post, we’ll break down:
- How Orlistat and Wegovy work
- Real UK results
- Side effects
- Costs
- Which one is better for sustainable weight loss
Whether you’re starting your journey or switching plans, this Orlistat vs Wegovy UK guide gives you everything you need.
💊 What is Orlistat?
Orlistat (Xenical® 120mg) is a fat-blocking weight loss pill available by prescription in the UK. It prevents about 25%–30% of fat from being absorbed by your body.
- Taken 3× daily with meals
- Suitable for people who prefer oral medication
- Ideal for BMI 30+ or BMI 28+ with risk factors
- Available in pharmacies across the UK
Best for: People who eat high-fat meals and want gradual fat loss support.
💉 What is Wegovy?
Wegovy (Semaglutide 2.4mg) is a weekly injection approved in the UK by the MHRA in 2023. It belongs to a class of medicines called GLP-1 receptor agonists, which:
- Suppress appetite
- Slow digestion
- Help reduce calorie intake naturally
Best for: People struggling with appetite, emotional eating, or who want to lose 10–20% of body weight.
📊 Orlistat vs Wegovy: Results & Effectiveness
| Feature | Orlistat | Wegovy |
|---|---|---|
| Weight loss (avg) | 4–8% of body weight | 15–20% of body weight |
| Time to results | 2–3 months | 4–6 weeks noticeable, 12–24 weeks full results |
| Mode | Blocks fat absorption | Suppresses appetite |
| Treatment type | Daily capsule | Weekly injection |
| MHRA Approved | ✅ Yes (as Xenical) | ✅ Yes (2023) |
✅ Wegovy is more effective for significant weight loss, while Orlistat is more accessible and suitable for mild weight reduction.
⚠️ Side Effects Comparison
Orlistat Side Effects:
- Oily stools
- Urgent bowel movements
- Flatulence
- Can be reduced by eating a low-fat diet
Wegovy Side Effects:
- Nausea
- Fatigue
- Constipation
- Indigestion
- Usually fade after 4–6 weeks
💷 Cost Comparison (UK Prices)
| Product | Pack Size | Approx. Price (GBP) |
|---|---|---|
| Orlistat | 84 capsules (28 days) | £39.99 – £59.99 |
| Wegovy | 1 pen (4 weeks) | £169.00 – £299.00 |
💡 Wegovy is more expensive but offers faster, long-term results.
🔄 Orlistat vs Wegovy: Which Is Better?
| Goal | Best Option |
|---|---|
| Mild weight loss | Orlistat |
| Strong appetite suppression | Wegovy |
| Fast results | Wegovy |
| Lower cost | Orlistat |
| Prescription required | Both |
🧠 Final Thoughts: Wegovy or Orlistat for UK Weight Loss?
If your goal is substantial, long-term weight loss, Wegovy is currently the most powerful treatment available in the UK. If you’re looking for a cheaper, fat-focused option, Orlistat is a reliable, clinically backed alternative.
🎯 Pro Tip: Always combine any weight loss treatment with a balanced diet and light exercise for best results.
